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A landmark study from researchers at Huntsman Cancer Institute at the (the U), the at the U, and found that women with severe endometriosis are 10 times more likely to get ovarian cancer, compared to women who do not have the disease.
Prior studies have shown a causal connection between and ovarian cancer. But in using the 鈥攁 repository of linked health records housed at Huntsman Cancer Institute鈥攊nvestigators were able to analyze the incidence rates of different types of endometriosis and subtypes of ovarian cancer for the first time.
Their research, which included a cohort of over 78,000 women with endometriosis, has been .
鈥淭hese are really important findings,鈥 says , investigator and co-leader of the at Huntsman Cancer Institute and professor of the population health sciences department at the U. 鈥淭his impacts clinical care for individuals with severe endometriosis, since they would benefit from counseling about ovarian cancer risk and prevention. This research will also lead to further studies to understand the mechanisms through which specific types of endometriosis cause different types of ovarian cancer.鈥
鈥淭hese are really important findings. This impacts clinical care for individuals with severe endometriosis, since they would benefit from counseling about ovarian cancer risk and prevention.鈥
Jennifer Doherty, PhD, MS
The project began as a collaboration between Doherty, , an assistant professor of medicine at Boston University Chobanian & Avedisian School of Medicine, and H, associate professor of public health at the U. Schliep served as senior and corresponding author of the study.
鈥淜aren [Schliep] was researching endometriosis, and Mollie [Barnard] and I were working on ovarian cancer. We mutually approached each other about putting the data from our two studies together, and that鈥檚 how this very powerful combined analysis happened,鈥 says Doherty. 鈥淚t鈥檚 hard to have a large enough study to be able to observe the results we did鈥攁ll thanks to the Utah Population Database.鈥
What is Endometriosis?
Endometriosis is a disease in which the tissue that lines the uterus grows elsewhere in the pelvic cavity, creating lesions on the ovaries, fallopian tubes, or behind the uterus. An estimated 11% of women in the United States, 6,500,000 in total, have the condition which often leads to chronic pain and infertility.
According to the , the disease presents in . Superficial endometriosis is mainly seen on the mucous membrane around the pelvic cavity. More severe forms are found as cysts within the ovaries called endometriomas and as deep infiltrating endometriosis, which affects the organs near the uterus, like the ovaries, bladder and bowels.
In the Utah-based cohort, researchers found that women suffering from more severe types of endometriosis are more likely to develop .
鈥淭hat's where we found a 19-fold increased risk, which compares to the connection between smoking and lung cancer,鈥 says Schliep. 鈥淎s an epidemiologist, seeing numbers like that is really striking.鈥
鈥淭hat's where we found a 19-fold increased risk, which compares to the connection between smoking and lung cancer. As an epidemiologist, seeing numbers like that is really striking.鈥
Karen Schliep, PhD, MSPH
In their calculations, they also found that women with any kind of endometriosis have a 4.2-fold risk of developing ovarian cancer compared to those who do not. They also have over 7 times the risk of developing type I ovarian cancer, which is slow to develop but also does not respond well to chemotherapy.
The National Cancer Institute says that ovarian cancer has a .
鈥淭he big question for women is 鈥榳hat can I do about it?鈥 This is important data for women to have as they're weighing what kind of treatments they should maybe undergo to avoid any kind of disease down the road,鈥 says Schliep. 鈥淚鈥檓 very passionate about giving women the right information and then having them be able to make shared decisions with their physician.鈥
As a preventative measure, women with endometriosis could pursue surgeries including a hysterectomy or removal of the ovaries. But these are invasive procedures, and investigators say more research is needed to know if these are the right measures.
鈥淥ften we're several steps away from drug development or clinical practice, but this feels like it's just a few steps away where it might take just a couple of clinical studies or implementation studies to figure out how this information can best be leveraged by doctors and their patients.鈥
Mollie Barnard, ScD
Barnard, a former postdoctoral student at Huntsman Cancer Institute, feels hopeful about the study鈥檚 ability to make an impact in women鈥檚 lives.
鈥淚 chose to become an epidemiologist to make a difference in people's lives, and often we're several steps away from drug development or clinical practice,鈥 says Barnard. 鈥淏ut this feels like it's just a few steps away where it might take just a couple of clinical studies or implementation studies to figure out how this information can best be leveraged by doctors and their patients.鈥
Other Huntsman Cancer Institute researchers who contributed to this landmark study include , , , , , and Kathryn Maurer, MD
This study was supported by the National Institutes of Health/National Cancer Institute including P30 CA042014 and Huntsman Cancer Foundation.
Media Contact
Heather Simonsen
Public Affairs Senior Manager
Huntsman Cancer Institute
801 581-3194
public.affairs@hci.utah.edu
About Huntsman Cancer Institute at the University of Utah
Huntsman Cancer Institute at the is the National Cancer Institute-designated Comprehensive Cancer Center for Utah, Idaho, Montana, Nevada, and Wyoming. With a legacy of innovative cancer research, groundbreaking discoveries, and world-class patient care, we are transforming the way cancer is understood, prevented, diagnosed, treated, and survived. Huntsman Cancer Institute focuses on delivering the most advanced cancer healing and prevention through scientific breakthroughs and cutting-edge technology to advance cancer treatments of the future beyond the standard of care today. We have more than 300 open clinical trials and 250 research teams studying cancer. More genes for inherited cancers have been discovered at Huntsman Cancer Institute than at any other cancer center. Our scientists are world-renowned for understanding how cancer begins and using that knowledge to develop innovative approaches to treat each patient鈥檚 unique disease. Huntsman Cancer Institute was founded by Jon M. and Karen Huntsman.