University of Utah professors ., professor and chair of Oncological Sciences and senior director of Basic Science at Huntsman Cancer Institute (HCI); , distinguished professor of Biochemistry; and , distinguished professor of Mathematics, were raised to a high honor in science today with their election to the .
The three scientists join 225 U.S. scholars, scientists, writers, artists, as well as civic, business and philanthropic leaders, elected by the Academy, which is headquartered in Cambridge, Mass. Members of the 2017 class include winners of the Pulitzer Prize and the Wolf Prize, MacArthur Fellows, Fields Medalists, Presidential Medal of Freedom and National Medal of Arts recipients, and Academy Award, Grammy Award, Emmy Award and Tony Award winners.
was honored for his work examining how chromatin, the structures that package chromosomal DNA, switch genes on or off. He is working to understand how changes in chromatin affect cellular mechanisms that can lead to cancer development. Cairns is using zebrafish to study genes associated with many types of cancers.
Along with this latest honor, Cairns has been a Howard Hughes Medical Institute Investigator since 2000.
"Dr. Cairns has made fundamental discoveries in the areas of DNA remodeling and regulation of gene expression that are influencing how we think about human development and disease," said Mary Beckerle, Ph.D., CEO and director of HCI. "In addition to his innovative and high-impact scientific work, Dr. Cairns is also an exceptional leader who has built a culture of excellence and collaboration at Huntsman Cancer Institute and the University of Utah. The American Academy of Arts and Sciences couldn't have chosen a better person to honor with membership in this distinguished society."
has been on the faculty at the U of U Health for 42 years. Starting 21 years ago, he developed the earliest of the precise genome editing platforms, zinc-finger nucleases. He has worked with ZFNs and the successor technologies, TALENs and CRISPR-Cas, all of which are being used around the world to learn the consequences of specific mutations, to improve agricultural plant and animals, and to develop treatments for human diseases.
Carroll received both the 2012 Edward Novitski Prize from the Genetics Society of America and the 2014 Herbert Sober Lectureship from the American Society of Biochemistry and Molecular Biology. He also received the 2016 Distinguished Innovation and Impact Award from the University of Utah.
"I am ecstatic to hear that Dr. Dana Carroll has been elected into the American Academy of Arts and Sciences," said U of U Vice President for Research Andrew Weyrich, Ph.D. "Dr. Carroll is a pioneer in the research community for his groundwork in genome editing platforms, which have been used effectively to modify the genomes of over 80 organisms. This is a great honor for his continuous dedication and contribution to research and science."
Christopher Hacon is a scholar of algebraic geometry, the field of mathematics that studies geometric objects defined by polynomial equations. He is particularly interested in objects that exist in more than three dimensions, and he and his colleagues have applied studies of these objects to extend the "minimal model program," a foundational principle of algebraic geometry, into higher dimensions. The American Mathematical Society has lauded the work of Hacon and his colleagues as "a watershed in algebraic geometry."
Hacon is a fellow of the American Mathematical Society and recipient of the 2016 EH Moore Research Article Prize, the 2015 Distinguished Scholarly and Creative Research Award from the University of Utah, the 2011 Antonio Feltrinelli Prize in Mathematics Mechanics and Applications, the 2009 Frank Nelson Cole Prize in Algebra and the 2007 Clay Research Award.
"Hacon's election as a member of the AAAS stands in recognition of his towering stature as a research mathematician and his deep contributions not only to the discipline of mathematics, but also to the University of Utah," said Peter Trapa, chair of the Department of Mathematics.
"It is an honor to welcome this new class of exceptional women and men as part of our distinguished membership," said Don Randel, Chair of the Academy's Board of Directors. "Their talents and expertise will enrich the life of the Academy and strengthen our capacity to spread knowledge and understanding in service to the nation."