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Wesley Sundquist, PhD, chair of the Department of Biochemistry at the University of Utah, together with molecular biologist Scott Emr, PhD, director of the Weill Institute for Cell and Molecular Biology at Cornell University. The Horwitz Prize recognizes investigators whose contributions in the fields of biology or biochemistry are deemed major contributions to medical science, with 51 of its 111 recipients later winning Nobel Prizes.
Sundquist and Emr are recognized for discovery of the ESCRT (Endosomal Sorting Complexes Required for Transport) pathway and its biological functions. Sundquist's work on HIV, the virus that causes AIDS, revealed how the virus uses ESCRT machinery for replication. Sundquist鈥檚 work on HIV assembly also helped to lay the foundation for a new highly effective, long-lasting drug developed by Gilead Sciences that has been shown to prevent HIV transmission in large phase 3 clinical trials.